Molecular Mechanisms and Lifelong Consequences of Prenatal Exposure to Psychoactive Substances
暫譯: 產前接觸精神活性物質的分子機制及其終身影響
Bukiya, Anna N., Ali, Declan W.
相關主題
商品描述
Misuse of psychoactive substances in the form of tobacco, alcohol, cannabis, or prescribed meds, affects the entire family. Besides visible consequences, substance misuse by prospective parents has an invisible target - the progeny. While consequences of some substance use (such as alcohol) on embryonic and fetal development are well known, others are less studied. This book aims at summarizing recent advances in our understanding of how maternal and paternal misuse of psychoactive substances affects the progeny starting from early development and finishing with lifelong consequences. Book aims to cover current knowledge on molecular mechanisms that drive negative consequences of early developmental exposure to well-known drugs of misuse, as well as substances that are traditionally covered to a lesser extend, such as prescription medications, and caffeine. Attention is also given to trans-generational effects of drug misuse, when such misuse occurs before the conception. Lastbut not least, consequences of both maternal and paternal drug misuse are explained. Book will be of interest to a rather large community of students, researchers, and practicians, who tackle everyday challenges of prenatal drug exposure whether at the level of laboratory animal models or at the bedside and at obstetrics offices. Book will also be of value to health- and childcare professionals, as it explains lifelong consequences of prenatal exposure to drugs of misuse. Chapters in the book are contributed by renowned experts in the respective fields, from all across the globe. The overarching goal of this book is to create a comprehensive collection of articles that reflect current knowledge in the field of substance abuse and early development, and to raise the professional awareness of this critical, yet, often under-recognized issue.
商品描述(中文翻譯)
濫用精神活性物質，如煙草、酒精、大麻或處方藥，會影響整個家庭。除了可見的後果外，未來父母的物質濫用還有一個看不見的目標——後代。雖然某些物質（如酒精）對胚胎和胎兒發展的影響已廣為人知，但其他物質的影響則研究較少。本書旨在總結我們對母親和父親濫用精神活性物質如何影響後代的理解，從早期發展開始，直到終生的後果。本書旨在涵蓋當前對於早期發展接觸到的知名濫用藥物所驅動的負面後果的分子機制的知識，以及傳統上研究較少的物質，如處方藥和咖啡因。書中也關注於藥物濫用的跨代影響，特別是當這種濫用發生在受孕之前。最後，母親和父親的藥物濫用後果也會被解釋。本書將吸引一個相當大的社群，包括學生、研究人員和實務工作者，他們在實驗動物模型或臨床和產科診所中面對產前藥物暴露的日常挑戰。本書對於健康和兒童護理專業人員也具有價值，因為它解釋了產前接觸濫用藥物的終生後果。本書的各章節由來自全球各地的知名專家撰寫。本書的總體目標是創建一個全面的文章集，反映物質濫用和早期發展領域的當前知識，並提高專業人士對這一關鍵但常常被忽視的問題的認識。
作者簡介
Dr. Anna N. Bukiya, PhD is Professor at the Department of Physiology, Addiction Science and Toxicology at the University of Tennessee Health Science Center. Dr. Bukiya's laboratory is focusing on lipid modulation of ion channel function in excitable tissues and sensitivity to drugs of abuse. Dr. Bukiya's work has been consistently funded by National Institutes of Health and private foundations. Dr. Bukiya has published 53 original research articles, authored or co-authored 10 reviews and 14 book chapters. Dr. Bukiya also co-edited three books and served as a sole editor on one book, all focused on the role of lipids in modulation of protein function during normal physiology and pathological conditions. Dr. Bukiya's lab utilizes mouse and non-human primate models of prenatal alcohol exposure, computational modelling of lipid-protein interactions, biochemical and fluorescence microscopy-based quantification of cellular processes, as well as cerebral artery diameter monitoring approaches ex vivo and in vivo. Dr. Bukiya is a current member of several societies, including Research Society on Alcohol, International Drug Abuse Research Society, American Society for Pharmacology and Experimental Therapeutics, and Biophysical Society.
Dr. Declan W. Ali, PhD, is a Full Professor and Dean at the University of Alberta, Faculty of Science. His research is multi-fold but largely focuses on developmental neurobiology, neurophysiology and cell biology. Dr. Ali's investigations are primarily in zebrafish, where he provides expertise in patch-clamp electrophysiology. Dr. Ali's current research focuses on the mechanisms that underlie synaptic development in the central and peripheral nervous systems. Early research focused on synaptic plasticity in the rodent hippocampus and specifically, the effects of tyrosine kinases in CA1 LTP, but over the last 25 years, he has made contributions identifying the mechanisms that underlie synapse formation and maturation, determining how the excitability properties of neurons and muscle fibers change during early development, and how this relates to animal behavior. Recent work has focused on the effects of alcohol and cannabinoids (THC, CBD and CBN) on neurodevelopment and pain/analgesia, showing that these compounds alter synaptic activity in the CNS and the peripheral nervous system when administered early in development, with effects (in some cases) that last into adulthood and the next generation of animals. Key collaborations have resulted in significant contributions in the field of cell biology and cancer research, particularly on the effects of tyrosine kinases and transient receptor potential channels.
He has published 77 peer reviewed publications, 4 book chapters and has peer reviewed >200 grant applications (NSERC, NIH, NSF, NRC), >150 manuscripts. He has been invited to give >30 seminars and has sat on the Editorial Boards of 4 journals. Dr. Ali's research is funded by Canadian federal and provincial funding agencies and he is a member several societies including the Society for Neuroscience, the Canadian Society for Neuroscience and the International Drug Abuse Research Society.
作者簡介(中文翻譯)
安娜·N·布基亞博士 (Dr. Anna N. Bukiya, PhD) 是田納西大學健康科學中心生理學、成癮科學與毒理學系的教授。布基亞博士的實驗室專注於脂質對可激發組織中離子通道功能的調節及對濫用藥物的敏感性。布基亞博士的研究工作持續獲得國家衛生研究院和私人基金會的資助。她已發表53篇原創研究文章，撰寫或共同撰寫10篇綜述文章和14章書籍章節。布基亞博士還共同編輯了三本書籍，並擔任一本書的唯一編輯，這些書籍均聚焦於脂質在正常生理和病理條件下調節蛋白質功能的角色。布基亞博士的實驗室利用小鼠和非人類靈長類動物的產前酒精暴露模型，進行脂質-蛋白質相互作用的計算建模，生化和螢光顯微鏡基於細胞過程的定量，以及腦動脈直徑的ex vivo和in vivo監測方法。布基亞博士目前是多個學會的成員，包括酒精研究學會、國際藥物濫用研究學會、美國藥理學與實驗治療學會及生物物理學會。
德克蘭·W·阿里博士 (Dr. Declan W. Ali, PhD) 是阿爾伯塔大學科學院的全職教授及院長。他的研究範疇多樣，但主要集中於發展神經生物學、神經生理學和細胞生物學。阿里博士的研究主要在斑馬魚中進行，並提供在膜片鉗電生理學方面的專業知識。阿里博士目前的研究重點是中央和周邊神經系統中突觸發展的機制。早期的研究集中於啮齒動物海馬體中的突觸可塑性，特別是酪氨酸激酶在CA1長期增強 (LTP) 中的影響，但在過去25年中，他對於突觸形成和成熟的機制、神經元和肌肉纖維在早期發展過程中興奮性特性如何改變，以及這如何與動物行為相關做出了貢獻。最近的研究集中於酒精和大麻素 (THC、CBD 和 CBN) 對神經發展和疼痛/鎮痛的影響，顯示這些化合物在早期發展中施用時會改變中樞神經系統和周邊神經系統的突觸活動，並且在某些情況下，這些影響會持續到成年及下一代動物。關鍵的合作使他在細胞生物學和癌症研究領域做出了重要貢獻，特別是在酪氨酸激酶和瞬時受體電位通道的影響方面。
他已發表77篇同行評審的出版物，4章書籍章節，並對超過200份資助申請 (NSERC、NIH、NSF、NRC) 和超過150篇手稿進行了同行評審。他受邀發表超過30場研討會，並擔任4本期刊的編輯委員會成員。阿里博士的研究由加拿大聯邦和省級資助機構資助，他是多個學會的成員，包括神經科學學會、加拿大神經科學學會和國際藥物濫用研究學會。
