Micro and Nano Techniques for the Handling of Biological Samples (Hardcover)

Jaime Castillo-León, Winnie Edith Svendsen, Maria Dimaki

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商品描述

Several micro- and nanomanipulation techniques have emerged in recent decades thanks to advances in micro- and nanofabrication. For instance, the atomic force microscope (AFM) uses a nano-sized tip to image, push, pull, cut, and indent biological material in air, liquid, or vacuum. Using micro- and nanofabrication techniques, scientists can make manipulation tools, such as microgrippers and nanotweezers, on the same length scale as the biological samples.

Micro and Nano Techniques for the Handling of Biological Samples reviews the different techniques available to manipulate and integrate biological materials in a controlled manner, either by sliding them along a surface (2-D manipulation), or by gripping and moving them to a new position (3-D manipulation). The advantages and drawbacks are mentioned together with examples that reflect the state-of-the-art in manipulation techniques for biological samples.

Thanks to the advances in micro- and nanomanipulation techniques, the integration of biomaterials with physical transducers has been possible, giving rise to new and highly sensitive biosensing devices. Although great progress has been made, challenges are still present. To understand the complex interactions between and inside biological samples, scientists will always be working on improving technologies to manipulate, transport, sort, and integrate samples in different environments. Balanced between simplicity for the beginner and hardcore theory for the more advanced readers, this book is the ideal launching point for sharpening the scientific tools required to address these challenges.

商品描述(中文翻譯)

近幾十年來,由於微觀和納米製造技術的進步,出現了多種微觀和納米操作技術。例如,原子力顯微鏡(AFM)使用納米尖端在空氣、液體或真空中成像、推拉、切割和壓痕生物材料。利用微觀和納米製造技術,科學家可以在與生物樣本相同的尺度上製造微夾子和納米鉗子等操作工具。

《微觀和納米技術用於處理生物樣本》回顧了不同的技術,以控制方式操作和整合生物材料,無論是沿著表面滑動(2D操作)還是抓取並移動到新位置(3D操作)。文中提到了優點和缺點,並列舉了反映生物樣本操作技術最新發展的例子。

由於微觀和納米操作技術的進步,將生物材料與物理傳感器集成已成為可能,從而產生了新型的高靈敏度生物感測器。儘管取得了巨大進展,但仍存在挑戰。為了理解生物樣本內部和之間的複雜相互作用,科學家將一直致力於改進技術,以在不同環境中操作、運輸、分類和整合樣本。本書既適合初學者簡單易懂,又適合高級讀者深入理解理論,是解決這些挑戰所需的科學工具的理想起點。