Alzheimer's Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift
Behl, Christian
- 出版商: Springer
- 出版日期: 2024-07-15
- 售價: $1,840
- 貴賓價: 9.5 折 $1,748
- 語言: 英文
- 頁數: 652
- 裝訂: Quality Paper - also called trade paper
- ISBN: 3031315723
- ISBN-13: 9783031315725
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商品描述
This book highlights the key phases and central findings of Alzheimer's Disease research since the introduction of the label 'Alzheimer's Disease' in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer's drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explainthe pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed?
In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer's research community only more recently.
With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer's Disease research.
商品描述(中文翻譯)
本書突顯了自1910年「阿茲海默症」這一標籤引入以來，阿茲海默症研究的關鍵階段和中心發現。作者Christian Behl將癡呆症研究置於當時的時代背景中，並總結了導致目前可用的阿茲海默症藥物的過程。在帶領讀者回顧阿茲海默症研究的主要發展，特別是在過去三十年中，Behl提出了關鍵問題：儘管全球在學術界和製藥行業進行了大量的研究努力，阿茲海默症的確切成因為何仍然不明？為什麼整個研究領域的大多數人仍然專注於一個假設，即將腦內的β-淀粉樣蛋白沉積視為阿茲海默病理的關鍵觸發因素，即使這一概念在臨床上仍未得到令人信服的證明？是否存在其他假設可以解釋這種複雜腦病的發病機制？如果有，為什麼這些觀點未能得到充分的關注？
在本書中，Behl試圖回答這些問題。從歷史背景開始，作者闡述了漫長而艱辛的研究旅程、無數的挫折以及對該疾病的許多替代解釋，這些解釋最近才開始在阿茲海默症研究社群中獲得越來越多的關注和接受。
通過深入探討這項研究的歷史和進展，包括最新的發展，Behl解釋了他為什麼認為現在是推動阿茲海默症研究範式轉變的最佳時機。
本書是為所有神經生物學和神經退行性疾病領域的研究者以及其他生物醫學領域的研究者所寫，旨在讓他們對這一當代最受推崇的研究領域之一有更廣泛且深入的了解。書中包含大量文獻參考和超過100幅插圖，對學生和感興趣的外行人也具有吸引力。作者詳細闡述了這一研究領域的各種不同方面和研究方法，旨在說服讀者，阿茲海默症的潛在成因可能比先前認為的要複雜得多，這必須在未來的研究方向中予以考慮。雖然他希望阿茲海默症研究社群最終能夠擺脫阻礙進展已久的「淀粉樣蛋白束縛」，但他也堅信，迫切需要的範式轉變可以指導未來的阿茲海默症研究，並為這種與年齡相關的腦病提供新的、更廣泛的視角。
作者簡介
Christian Behl is Professor of Pathobiochemistry and Director of the Institute of Pathobiochemistry at the University Medical Center of the Johannes Gutenberg University Mainz, Germany. He has been closely following Alzheimer's Disease research since the early 1990's, when he first got involved into the field himself during his time at the Salk Institute for Biological Studies, La Jolla, USA. He stayed active in the field all through his research station at the Max Planck Institute of Psychiatry, Munich, Germany, and later in Mainz. There his current research (in Mainz) focuses on the cellular degradation mechanism autophagy in the context of neurodegeneration and aging. For quite some time Behl has been an active advocate for widening the focus of Alzheimer's Disease research to improve the understanding of this complex, age-related brain disorder. Behl is member of several scientific boards, including the German Alzheimer Foundation.
作者簡介(中文翻譯)
Christian Behl 是德國美因茲約翰·古騰堡大學醫學中心的病理生化學教授及病理生化學研究所所長。他自1990年代初期以來一直密切關注阿茲海默症的研究，當時他在美國拉荷亞的索克生物研究所首次參與該領域。在他於德國慕尼黑的馬克斯·普朗克精神病學研究所的研究期間，以及後來在美因茲，他一直活躍於該領域。目前他在美因茲的研究專注於神經退行性疾病和衰老背景下的細胞降解機制自噬。Behl 一直積極倡導擴大阿茲海默症研究的焦點，以改善對這種複雜的與年齡相關的腦部疾病的理解。Behl 是多個科學委員會的成員，包括德國阿茲海默基金會。
