Abnormal Morphology of Bovine Spermatozoa

本書提供了關於牛隻生育力的廣泛視角，重點在於牛精子缺陷的分類和解釋。

在1989年首次出版的成功基礎上，本新版本已大幅更新和擴展，以反映過去三十年的發展。各章節涵蓋了牛精子的正常與異常發展、精子缺陷背後的機制，以及這些缺陷對生育力的影響。特別關注基因組研究的進展，以及在評估公牛生育力時使用精子質量生物標記和基因篩檢測試。此外，本書還探討了公牛性發展的關鍵時期，如早期妊娠和斷奶前。

本專著旨在為動物繁殖領域的研究人員和學生、獸醫以及動物科學家提供參考。它深入探討了牛隻生育力，這對於任何從事畜牧生產或相關領域的人來說都是至關重要的。從本書中獲得的知識將對那些尋求提高畜牧生產力的人士有所裨益，進而為全球食品安全作出貢獻。

Albert Barth received his DVM degree from the University of Saskatchewan in 1971 and worked in private practice for 7 years. He received a Master of Veterinary Science degree in 1978, and board certification in the American College of Theriogenologists in 1982. For the remainder of his career he was on faculty at the Western College of Veterinary Medicine, University of Saskatchewan involved in teaching, clinical service, and research. He received professorship in 1987 and retired in 2013. His main research interests were in applied Theriogenology with emphasis in bull fertility. Specific interests included spermatology, pubertal development, reproductive diseases, and mating performance. Dr. Barth was instrumental in getting the first edition of the book, 'Abnormal Morphology of Bovine Spermatozoa' by Barth and Oko, published by Iowa Press in 1989.

Viv Perry obtained her PhD in bull fertility from the School of Veterinary Science at the University of Queensland in 1988. Her postdoctoral fellowship focused on fetal programming (FP) in the heifer, with particular emphasis upon the effect of gestational diet upon reproductive development of the offspring. In 2011, she was appointed Associate Professor at the School of Veterinary and Medical Science, University of Nottingham. Dr. Perry's leadership in UK and Australian Universities, of large-scale bovine research studies into both FP and bull fertility, has enabled a greater understanding of the role of diet upon bovine development and fertility. She holds honorary research positions at both the University of Queensland and Adelaide and manages Commercial Semen Laboratories.

Lauren E. Hamilton earned her PhD in Biomedical and Molecular Sciences specializing in Reproduction and Development from Queen's University, Kingston, Ontario, Canada in 2019. She was a postdoctoral research fellow at the University of Missouri-Columbia from 2020-2024 and a 2021 Lalor Foundation Fellowship recipient. Her work focuses on the proteomic composition of mammalian sperm structures, the genomic origins of sperm morphology defects and the use of sperm nanopurification technology to improve the overall sperm quality of a bovine ejaculate.

Peter Sutovsky earned his PhD degree from the Czech Academy of Sciences in 1994. He was a Postdoctoral Fellow at the University of Wisconsin, Madison WI, and Staff Scientist at the Oregon Health & Science University, Portland OR, before his 2001 faculty appointment at the University of Missouri, Columbia MO, where he is currently a Professor of Animal Science, and Obstetrics, Gynecology and Women's Health. He is recognized for his studies of mammalian gametogenesis, fertilization, and embryo development with emphasis on the gamete and zygotic ubiquitin-proteasome system (UPS). He was the first to describe the role of UPS in the regulation of mitochondrial inheritance, and introduced the concept of extracellular UPS and its role in sperm maturation and fertilization. His most recent work focuses on biomarker-based flow cytometric semen analysis, semen nanopurification, sperm genome-to-phenotype research, and sperm capacitation studies aimed at improving conception rates in livestock and humans.

Richard Oko obtained his PhD in Veterinary Anatomy from the University of Saskatchewan in 1984, under the supervision of Dr. Francis Hrudka. Following this, he accepted a postdoctoral position, funded by an Alberta Heritage Foundation for Medical Research scholarship, under Dr. Yves Clermont at McGill University, where subsequently he was appointed Assistant Professor. Dr. Oko then joined the Department of Anatomy and Cell Biology at Queen's University (now the Department of Biomedical and Molecular Sciences) becoming a Full Professor in 2004. His research program in reproductive biology received continual research funding from the Natural Sciences and Engineering Research Council and the Canadian Institutes of Health Research. He is recognized for studies on the developmental biology of specialized mammalian sperm head and tail components, their molecular composition and their roles during fertilization.

Albert Barth於1971年獲得薩斯喀徹溫大學的獸醫學博士學位，並在私人執業工作了7年。他於1978年獲得獸醫科學碩士學位，並於1982年獲得美國獸醫生殖學會的專業認證。在他職業生涯的剩餘時間裡，他在薩斯喀徹溫大學的西部獸醫學院擔任教職，參與教學、臨床服務和研究。他於1987年獲得教授職稱，並於2013年退休。他的主要研究興趣在於應用獸醫生殖學，特別是公牛的生育能力。具體興趣包括精子學、青春期發展、生殖疾病和交配表現。Barth博士在1989年促成了《牛精子異常形態學》一書的首次出版，該書由Barth和Oko合著，並由愛荷華大學出版社出版。

Viv Perry於1988年在昆士蘭大學的獸醫科學學院獲得公牛生育的博士學位。她的博士後研究專注於小母牛的胎兒編程（FP），特別強調妊娠飲食對後代生殖發展的影響。2011年，她被任命為諾丁漢大學獸醫與醫學科學學院的副教授。Perry博士在英國和澳大利亞大學領導的大規模牛隻研究，對FP和公牛生育的研究，增進了對飲食在牛隻發展和生育中角色的理解。她在昆士蘭大學和阿德萊德大學擔任榮譽研究職位，並管理商業精液實驗室。

Lauren E. Hamilton於2019年在加拿大安大略省金士頓的女王大學獲得生物醫學與分子科學博士學位，專攻生殖與發展。她於2020年至2024年在密蘇里大學哥倫比亞校區擔任博士後研究員，並於2021年獲得Lalor基金會獎學金。她的研究專注於哺乳動物精子結構的蛋白質組成、精子形態缺陷的基因組來源，以及使用精子納米純化技術來改善牛隻射精的整體精子質量。

Peter Sutovsky於1994年獲得捷克科學院的博士學位。他曾在威斯康辛大學麥迪遜校區擔任博士後研究員，並在俄勒岡健康與科學大學擔任科學家，之後於2001年在密蘇里大學哥倫比亞校區獲得教職，目前是動物科學、婦產科及婦女健康的教授。他因研究哺乳動物的配子生成、受精和胚胎發展而受到認可，特別是對配子和合子泛素-蛋白酶體系統（UPS）的研究。他是首位描述UPS在調節線粒體遺傳中的角色的學者，並引入了細胞外UPS及其在精子成熟和受精中的作用的概念。他最近的研究專注於基於生物標記的流式細胞儀精液分析、精液納米純化、精子基因組到表型的研究，以及旨在提高家畜和人類受孕率的精子活化研究。

Richard Oko於1984年在薩斯喀徹溫大學獲得獸醫解剖學博士學位，指導教授為Francis Hrudka博士。隨後，他接受了由阿爾伯塔醫學研究遺產基金會資助的博士後職位，於麥吉爾大學的Yves Clermont博士指導下，並隨後被任命為助理教授。Oko博士隨後加入女王大學的解剖學與細胞生物學系（現為生物醫學與分子科學系），並於2004年成為正教授。他的生殖生物學研究計劃持續獲得自然科學與工程研究委員會的研究資助。