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商品描述
This volume brings together pre-clinical and clinical research on topics highly relevant to the development and improvement of our understanding of Alzheimer's disease (AD). The combination of both research areas will appeal to a broad range of researchers from basic scientists to neurologists. The topics cover both established and more recent areas of research on the underlying causes of this disease which are still not fully understood more than 100 years after its first description by Alois Alzheimer. This broad perspective demonstrates how research into AD is evolving along with considering clinical aspects of the disease. The chosen contributors are well-placed to provide expert views on these topics. The book is divided into 2 sections, pre-clinical research and clinical research. While each section contains unique topics, there are also topics common to both areas such as Down Syndrome, considerations of diversity and behavioural and neurobiological symptoms of dementia to provide a wider perspective on these topics. The inclusion of Down Syndrome demonstrates the reverse translation of knowledge from the clinic to laboratory-based neurobiology. The two main sections are then further subdivided into groups for related topics. The broad overview of this book will encourage researchers to pursue bold and innovative research to expand knowledge of this complex neurodegenerative disease and to improve its detection, diagnosis, treatment, and management.
商品描述(中文翻譯)
本卷匯集了與阿茲海默症(Alzheimer's disease, AD)發展及改善我們對該疾病理解高度相關的前臨床及臨床研究。這兩個研究領域的結合將吸引從基礎科學家到神經科醫生的廣泛研究者。這些主題涵蓋了該疾病的既有研究及較新研究領域,儘管距離阿洛伊斯·阿茲海默(Alois Alzheimer)首次描述該疾病已超過100年,但其根本原因仍未完全理解。這種廣泛的視角展示了對阿茲海默症的研究如何隨著考慮臨床方面而演變。所選的貢獻者在這些主題上具備提供專業見解的良好位置。本書分為兩個部分:前臨床研究和臨床研究。雖然每個部分包含獨特的主題,但也有一些主題在兩個領域中是共同的,例如唐氏症(Down Syndrome)、多樣性考量以及癡呆的行為和神經生物學症狀,以提供這些主題的更廣泛視角。唐氏症的納入展示了從臨床到實驗室基礎神經生物學的知識反向轉譯。這兩個主要部分進一步細分為相關主題的組別。本書的廣泛概述將鼓勵研究者追求大膽且創新的研究,以擴展對這種複雜神經退行性疾病的知識,並改善其檢測、診斷、治療和管理。