This book systematically discusses the pathogenesis, prevention, and the current and potential clinical treatment of hearing loss, as well as the latest advances in hearing research. Hearing loss is a prevalent sensory disorder, which according to a 2015 World Health Organization (WHO) report affected 9% of the global population in 2015. As populations continue to age, more and more people are suffering from the condition, with 60% of those aged between 65 and 75 affected. Hearing loss seriously affects patients' ability to work ability and quality of life, and as such deafness has become an increasingly urgent social problem around the globe. Sensorineural hearing loss is mainly caused by damage to the hair cells (HCs), and the subsequent loss of spiral ganglion neurons (SGNs). Damage to the HCs in the inner ear can result from exposure to loud noises and environmental and chemical toxins as well as genetic disorders, aging, and certain medications. This book provides ENT specialists and researchers, as well as individuals affected a comprehensive introduction to the field of hearing loss.
本書系統性地討論了聽力損失的發病機制、預防措施以及當前和潛在的臨床治療方法，並介紹了聽力研究的最新進展。聽力損失是一種普遍的感覺障礙，根據2015年世界衛生組織（WHO）的報告，2015年全球有9%的人口受到影響。隨著人口持續老化，越來越多的人受到這種情況的困擾，其中65至75歲的人群中有60%受到影響。聽力損失嚴重影響患者的工作能力和生活品質，因此失聰已成為全球日益緊迫的社會問題。感音神經性聽力損失主要是由於毛細胞（HCs）的損傷，以及隨後螺旋神經節神經元（SGNs）的喪失。內耳中HCs的損傷可能是由於暴露於噪音、環境和化學毒素，以及遺傳疾病、老化和某些藥物所造成。本書為耳鼻喉科專家和研究人員，以及受到影響的個體提供了聽力損失領域的全面介紹。
Dr. Huawei Li, M.D. is a Professor, Chief Physician and doctoral and post doctoral mentor, and was appointed Chairman of the Department of Otorhinolaryngology Affiliated Eye and ENT Hospital in 2016. His other appointments include Vice-chairman of NHC Key Laboratory of Hearing Medicine, President of the Shanghai Otolaryngology Doctors' Association, Vice-president of Shanghai Medical Association of Otolaryngology Head and Neck Surgey, member of the Chinese Medical Association of Otolaryngology Head and Neck Surgery. He is also Chief Scientist of 973 National Project of China and of the National Key R&D Program of China, Specially-appointed Professor in the Yangtze River Scholar Program, Laureate of National Outstanding Youth Science Fund, Shanghai Excellent Discipline Leaders, Visiting Professor of Massachusetts Eye and Ear Infirmary, Harvard Medical School. He has also received an honorary title for his outstanding contribution to NHC. His research focuses on otomicrosurgery, stem cell transcriptional regulation, and hair cell regeneration. He has published more than 100 papers, including in Nature Medicine and PNAS.
Dr. Renjie Chai, Ph.D., is a Professor and Assistant Dean of the Institute of Life Sciences, Southeast University. His other appointments include Vice-president of the Association of Hearing, Speech and Communication in Biophysical Society of China, executive board member of the International Association of Physicians in Audiology. He is the winner of the National Natural Science Foundation of China Excellent Youth Fund and of the 1000 Young Talents Recruitment Plan of China, and has been awarded more than 20 grants including the National Key R&D Program of China, the Strategic Priority Research Program of the Chinese Academy of Science, and a Faculty Research Award from Boehringer Ingelheim and Novartis. His research focuses on the regeneration and protection of inner ear hair cells and spiral ganglion neurons. He has published more than 70 papers, including in Advanced Materials, Nature Communications, and PNAS.
華為李醫生（Dr. Huawei Li, M.D.）是教授、主任醫師及博士與博士後導師，於2016年被任命為附屬眼耳鼻喉醫院耳鼻喉科主任。他的其他職位包括國家衛生健康委員會聽力醫學重點實驗室副主任、上海耳鼻喉科醫師協會會長、上海耳鼻喉科醫學會副會長，以及中國耳鼻喉科醫學會頭頸外科委員會成員。他同時也是中國973國家專案的首席科學家及國家重點研發計畫的首席科學家，長江學者特聘教授，國家優秀青年科學基金獲獎者，上海優秀學科帶頭人，哈佛醫學院麻省眼耳醫院的客座教授。他因對國家衛生健康委員會的傑出貢獻而獲得榮譽稱號。他的研究重點在於耳顯微外科、幹細胞轉錄調控及毛細胞再生。他已發表超過100篇論文，包括在《Nature Medicine》和《PNAS》上。
蔡仁杰博士（Dr. Renjie Chai, Ph.D.）是東南大學生命科學研究所的教授及助理院長。他的其他職位包括中國生物物理學會聽力、語言及溝通協會副會長、國際聽力醫師協會執行委員會成員。他是國家自然科學基金優秀青年基金的獲獎者及中國千人計畫的獲獎者，並獲得超過20項資助，包括國家重點研發計畫、中國科學院戰略性優先研究計畫，以及Boehringer Ingelheim和Novartis的教職研究獎。他的研究重點在於內耳毛細胞及螺旋神經節神經元的再生與保護。他已發表超過70篇論文，包括在《Advanced Materials》、《Nature Communications》和《PNAS》上。
