Genetics and Epigenetics of Breast Cancer

本書討論了基因和表觀遺傳變異在乳腺癌的發生、發展和復發中的貢獻。它還回顧了將表觀遺傳變異轉化為乳腺癌診斷、預後和治療的潛力。最初的章節探討了乳腺癌的表觀遺傳學、病因學和常規治療策略。接下來的章節討論了基因景觀，並涵蓋了三種主要的表觀遺傳調節機制：組蛋白修飾、DNA甲基化和miRNA沉默。此外，本書還探討了表觀遺傳藥物在乳腺癌治療中的潛力。最後，它涵蓋了針對乳腺癌治療中的表觀遺傳調節因子的植物化學物質。本書是研究人員和從業人員探索表觀遺傳調節因子在乳腺癌治療中潛力的重要資源。

Dr. Madhumita Roy is currently the Assistant Director and Head of the Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, Kolkata. Her research focuses on cancer biology, environmental toxicology, and identification of important tumor bio-markers, and chemo-enhancing efficacy of tumor cells by plant-derived molecules. She has published over 80 research articles in journals of high repute. She is a life member of several societies, such as the Environment Mutagen Society of India (EMSI), Indian Association for Cancer Research (IACR), Electron Microscope Society of India, Indian Science Congress Association, All India Congress of Cytology & Genetics, and the Society of Nutraceuticals & Chronic Diseases.

Dr. Jaydip Biswas completed his MBBS, MS(Master of Surgery in general surgery) and Diploma in Medical Therapeutics from University of Calcutta, FRCS Ed from the Royal College of Surgeons of Edinburg, FACSfrom the American College of Surgeons and PhD in Medicine from University of Calcutta. He has worked in various roles in several hospitals, and in particular at the Chittaranjan National Cancer Institute, Kolkata, where he was an officer in charge, surgeon, and director between 2013 and 2018. He has received further medical training Memorial Sloan Kettering Cancer Centre, New York, and Manchester University Hope Hospital, Salford, UK and Christie Hospital, UK, in surgical oncology. He has extensive clinical expertise in different types of elective, emergency general surgical procedures including different types of cancer surgery, Head & Neck Reconstructive procedures, Breast Reconstruction and GI Endoscopy. He has taught many courses on surgical oncology at Chittaranjan National Cancer Institute. He has extensive research experience in various cancers and published over 70 papers in leading national and international journals in cancer, in particular on the role of phytochemicals in cancer treatment. He has also conducted many phase II and phase III clinical trials for potential therapies by drugs and phytochemicals in various cancers.

Dr. Amitava Datta is currently a professor at the Department of Computer Science and Software Engineering at the University of Western Australia. He has completed his M.Tech and PhD in Computer Science at the Indian Institute of Technology, Madras. He pursued postdoctoral research at the Max Planck Institute for Computer Science and University of Freiburg, both in Germany. He was a Visiting Professor at the University of Freiburg and is currently a Visiting Professor at the University of Life Sciences, Warsaw, Poland, and South West University, China. His scientific interests include computational molecular biology, data mining and parallel and distributed computing, and his computational molecular biology research focuses on RNA structural biology and miRNA gene and target prediction, particularly in relation to cancer biology. He has published over 150 research papers in respected international journals.

Dr. Madhumita Roy目前擔任印度加爾各答的Chittaranjan National Cancer Institute環境致癌與毒理學部門的助理主任和主管。她的研究專注於癌症生物學、環境毒理學、重要腫瘤生物標記的鑑定，以及植物衍生分子對腫瘤細胞的化療增效作用。她在高聲望期刊上發表了80多篇研究文章。她是多個學會的終身會員，包括印度環境突變學會（EMSI）、印度癌症研究協會（IACR）、印度電子顯微鏡學會、印度科學大會協會、全印度細胞學和遺傳學大會，以及營養補助品和慢性疾病學會。

Dr. Jaydip Biswas在加爾各答的卡爾卡塔大學獲得MBBS、MS（普通外科碩士）和醫學治療學文憑，並在愛丁堡皇家外科醫師學院獲得FRCS Ed、在美國外科醫師學院獲得FACS，以及在卡爾卡塔大學獲得醫學博士學位。他在多家醫院擔任過不同職位，特別是在加爾各答的Chittaranjan National Cancer Institute，他在2013年至2018年期間擔任過負責官、外科醫師和主任。他在紐約的Memorial Sloan Kettering Cancer Centre、英國曼徹斯特大學Hope Hospital和Christie Hospital接受了進一步的外科腫瘤醫學培訓。他在不同類型的選擇性和緊急普通外科手術，包括不同類型的癌症手術、頭頸部重建手術、乳房重建和胃腸內視鏡檢查方面具有豐富的臨床專業知識。他在Chittaranjan National Cancer Institute教授了許多外科腫瘤學課程。他在各種癌症方面擁有廣泛的研究經驗，並在癌症領域的領先國內外期刊上發表了70多篇論文，特別是關於植物化學物在癌症治療中的作用。他還在各種癌症中進行了許多二期和三期臨床試驗，評估藥物和植物化學物的潛在治療方法。

Dr. Amitava Datta目前是澳大利亞西澳大學計算機科學和軟件工程系的教授。他在印度馬德拉斯的印度理工學院完成了計算機科學的碩士和博士學位。他在德國的馬克斯普朗克計算機科學研究所和弗賴堡大學進行了博士後研究。他曾是弗賴堡大學的客座教授，目前是波蘭華沙大學生命科學和中國西南大學的客座教授。他的科學興趣包括計算分子生物學、數據挖掘和並行和分佈式計算，他的計算分子生物學研究專注於RNA結構生物學和miRNA基因和靶標預測，特別是與癌症生物學相關的領域。他在國際知名期刊上發表了150多篇研究論文。