Cardiovascular Applications of Stem Cells

Haider, Khawaja H.

Cardiovascular Applications of Stem Cells
  • 出版商: Springer
  • 出版日期: 2024-07-06
  • 售價: $7,720
  • 貴賓價: 9.5 折 $7,334
  • 語言: 英文
  • 頁數: 514
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 9819907241
  • ISBN-13: 9789819907243

    • 海外代購書籍(需單獨結帳)

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商品描述

The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, the book also reviews the stem cell-derived exosomes, their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models. Additionally, the book also discusses the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protects the cells and their retention post-engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy.


商品描述(中文翻譯)

本書涵蓋了基於幹細胞的心血管疾病治療的多方面內容。除了來自不同來源的幹細胞用於細胞治療外，還探討了幹細胞類器官和幹細胞衍生的外泌體在再生醫學中的應用。本書還包括了先進基礎設施的進展，以改善多能幹細胞衍生心肌細胞的成熟性，使用一種新型的基於支架的細胞培養系統進行細胞傳遞，適用於實驗動物模型和臨床環境。除了使用間充質幹細胞外，本書還包含了有關心臟前體細胞（CPCs）、微組織植入、使用多能幹細胞（PSCs）治療瓣膜病、去細胞化器官陣列作為心臟組織工程的天然支架、使用心外膜幹細胞以及骨骼肌母細胞在心肌再生的細胞治療中的應用的章節。除了細胞治療方法外，本書還回顧了幹細胞衍生的外泌體、其特性以及增強其治療潛力的工程策略，包括靶向和藥物負載及其在疾病模型中的應用。此外，本書還討論了最新的可注射水凝膠在心血管再生中的研究，以及基於水凝膠的傳遞如何保護細胞及其在心臟移植後的保留，這是一個顯著降低細胞治療效果的問題。

作者簡介

Dr. Khawaja Husnain Haider is currently a Professor of Cellular and Molecular Pharmacology (Stem cells and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University. Before his current assignment, he served in several prestigious institutions in various parts of the world. He has also served as Principal Investigator (PI) and Co-PI on multiple National Institute of Health (NIH) funded stem cell research projects. He has been on the editorial boards of various research journals and an invited reviewer for several respected international journals. His research focuses on using DNA, miRNAs, and stem cells as "drugs," a topic that has gained popularity in regenerative medicine. He has published nearly 325 book chapters, abstracts, and research papers in various books and leading research journals, including Circulation, Circulation Research, Cardiovascular Research, JCMM, the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling. He has also given numerous presentations and edited seven books covering various facets of stem cells and their applications from drug to drug development.

作者簡介(中文翻譯)

Dr. Khawaja Husnain Haider 目前是蘇萊曼阿爾拉吉大學的細胞與分子藥理學（幹細胞與基因治療）教授及基礎科學系（醫學課程）主任。在目前的職位之前，他曾在世界各地的多個知名機構任職。他還擔任過多個國立衛生研究院（NIH）資助的幹細胞研究項目的首席研究員（PI）和共同首席研究員（Co-PI）。他曾擔任多個研究期刊的編輯委員會成員，並受邀為幾本受尊敬的國際期刊的審稿人。他的研究專注於將DNA、miRNAs和幹細胞作為“藥物”的應用，這一主題在再生醫學中越來越受歡迎。他已在各種書籍和領先的研究期刊上發表了近325篇書章、摘要和研究論文，包括《Circulation》、《Circulation Research》、《Cardiovascular Research》、《JCMM》、《Journal of Biological Chemistry》、《Cell Cycle》、《Basic Research in Cardiology》和《Antioxidant Redox Signaling》。他還進行了多次演講，並編輯了七本書，涵蓋幹細胞及其從藥物到藥物開發的各種應用面向。

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