Chitosan Nanoparticles for Brucellosis Treatment
暫譯: 幾丁聚糖奈米粒子於布魯氏菌病治療中的應用

Haider, Ali, Shahzadi, Iram, Kiran, Sehrish

Chitosan Nanoparticles for Brucellosis Treatment
  • 出版商: Springer
  • 出版日期: 2026-02-21
  • 售價: $7,400
  • 貴賓價: 9.5 折 $7,030
  • 語言: 英文
  • 頁數: 101
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3032162912
  • ISBN-13: 9783032162915
  • 相關分類: 生物資訊 Bioinformatics

    • 海外代購書籍(需單獨結帳)

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商品描述

This book offers an in-depth exploration of chitosan nanoparticles as an innovative therapeutic strategy for brucellosis, a notable zoonotic disease impacting both livestock and humans globally. The integration of nanotechnology and veterinary medicine explores the synthesis, characterization, and biological applications of chitosan-based nanocarriers, highlighting their potential to transform antimicrobial treatments. The book's first chapter commences with comprehensive introduction to chitosan, detailing its chemistry, solubility, viscosity, and biological properties, which encompass antibacterial, antioxidant, and anti-inflammatory activities. The book systematically outlines advanced synthesis protocols for chitosan nanoparticles, encompassing various techniques including ionotropic gelation, spray drying, nanoprecipitation, and covalent cross-linking. This analysis rigorously evaluates the methodologies to emphasize their effectiveness, scalability, and contribution to nanoparticle stability and bioactivity. The techniques for characterization are essential for comprehending nanoparticle behavior. The third chapter offers an in-depth exploration of size analysis, dynamic light scattering, atomic force microscopy, surface charge determination, and morphological studies utilizing scanning and transmission electron microscopy. These tools are crucial for enhancing nanoparticle design for targeted drug delivery. The fourth chapter focuses on bovine brucellosis, detailing its historical background, etiology, transmission, pathogenesis, and zoonotic potential of Brucella infections. The discussion encompasses contemporary diagnostic methods, therapeutic barriers, and management strategies, highlighting the necessity for novel treatment options. The primary emphasis of the book is on the function of chitosan nanoparticles in the treatment of brucellosis. The fifth chapter investigates nano-drug delivery systems, in vivo experimentation, and drug-loaded chitosan nanoparticles aimed at targeting Brucella infections. The proposed mechanism of action illustrates the methods by which these nanoparticles improve drug bioavailability, facilitate controlled release, and address antimicrobial resistance, and finally, the book concludes with an analysis of current challenges and future research directions, offering an outline for the integration of nanomedicine into veterinary and biomedical sciences. This book serves as a crucial resource for veterinary researchers, microbiologists, pharmaceutical scientists, and experts in nanomedicine who are pursuing advanced strategies to address brucellosis through innovative nanoparticle-based therapies.

商品描述(中文翻譯)

本書深入探討了幾丁糖奈米粒子作為一種創新的治療策略，用於布魯氏菌病（brucellosis），這是一種影響全球牲畜和人類的顯著人畜共通疾病。納米技術與獸醫醫學的結合探討了幾丁糖基奈米載體的合成、特徵化及生物應用，突顯了其在改變抗微生物治療方面的潛力。本書的第一章以全面介紹幾丁糖開始，詳細說明其化學性質、溶解度、黏度及生物特性，包括抗菌、抗氧化及抗發炎活性。本書系統性地概述了幾丁糖奈米粒子的先進合成方案，涵蓋了各種技術，包括離子膠化（ionotropic gelation）、噴霧乾燥（spray drying）、奈米沉澱（nanoprecipitation）及共價交聯（covalent cross-linking）。這一分析嚴格評估了這些方法，以強調其有效性、可擴展性及對奈米粒子穩定性和生物活性的貢獻。特徵化技術對於理解奈米粒子的行為至關重要。第三章深入探討了尺寸分析、動態光散射、原子力顯微鏡、表面電荷測定及利用掃描和透射電子顯微鏡的形態學研究。這些工具對於增強奈米粒子的設計以實現靶向藥物傳遞至關重要。第四章專注於牛布魯氏菌病，詳細介紹了其歷史背景、病因、傳播、發病機制及布魯氏菌感染的人畜共通潛力。討論涵蓋了當前的診斷方法、治療障礙及管理策略，突顯了對新治療選擇的必要性。本書的主要重點是幾丁糖奈米粒子在布魯氏菌病治療中的作用。第五章探討了奈米藥物傳遞系統、體內實驗及針對布魯氏菌感染的藥物負載幾丁糖奈米粒子。所提出的作用機制說明了這些奈米粒子如何改善藥物的生物利用度、促進控制釋放及應對抗微生物抗藥性。最後，本書以對當前挑戰和未來研究方向的分析作結，提供了將納米醫學整合到獸醫和生物醫學科學中的大綱。本書是獸醫研究人員、微生物學家、藥物科學家及納米醫學專家追求通過創新的奈米粒子基療法解決布魯氏菌病的關鍵資源。

作者簡介

Dr. Ali Haider obtained his master's degree (M.Phil., clinical medicine) from University of Veterinary and Animal Sciences (UVAS), Pakistan, in 2015. He obtained his Ph.D. degree in clinical medicine from the Department of Veterinary Medicine (UVAS), Lahore, in 2021. He served as Dairy Farm Manager at reputed commercial dairies of Punjab (Pakistan). Later on (January 2022-to date), Ali joined the Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture Multan (MNS-UAM), as Assistant Professor of clinical medicine. His research interest involves the veterinary clinical medicine, green synthesis and characterization of inorganic semiconductor nanomaterials, polymeric nanostructures, 2D materials for their catalytic, antiparasitic, and antibacterial evaluation against multiple drug-resistant (MDR) pathogens.

Dr. Iram Shahzadi obtained her M.Phil. in pharmaceutical chemistry from Punjab University College of Pharmacy (PUCP), University of the Punjab, Lahore, Pakistan, in 2019 and awarded with University Gold Medal. She completed her Ph.D. from PUCP in 2024. In November 2023, Iram joined the School of Pharmacy, University of Management and Technology (UMT), Lahore, as Assistant Professor of Pharmaceutical Chemistry. Iram was recognized among the top 2% of scientists worldwide in 2024 by Stanford University and Elsevier. Her research interests encompass green synthesis, polymeric nanocomposite synthesis and characterization for water treatment, antioxidant, anti-inflammatory activities. She also focuses on drug loading and release mechanisms for anti-cancer drugs, exploring their cytotoxicity potential against various cell lines and computational studies as in silico modeling and density functional theory (DFT) studies.

Sehrish Kiran obtained her B.S. (chemistry) degree from Lahore College for Women University (LCWU), Lahore (Punjab, Pakistan), in 2020. Sehrish completed her master's degree (M.S. in chemistry) from LCWU, Pakistan, in 2022 with research work focused on removal of heavy metals from wastewater using agricultural waste. Her research interest includes synthesis and characterization of polymeric and green nanomaterials with targeted drug delivery and therapeutics, catalytic degradation, and bactericidal evaluations.

Kashaf Shakoor obtained her B.S. degree in zoology from Government College University, Faisalabad (GCUF), Punjab, Pakistan, in 2023. She is now enrolled as M.S. Zoology Student in Muhammad Nawaz Shareef University of Agriculture, Multan (MNS-UAM), Pakistan. Her research interest focuses on synthesis and characterization of polymeric nanostructures with their catalytic and bactericidal evaluations to overcome antibacterial resistance in livestock and fish industry.

作者簡介(中文翻譯)

阿里·海德博士於2015年在巴基斯坦的獸醫與動物科學大學（University of Veterinary and Animal Sciences, UVAS）獲得臨床醫學碩士學位（M.Phil.）。他於2021年在拉合爾的獸醫醫學系（UVAS）獲得臨床醫學博士學位。他曾在巴基斯坦旁遮普省的知名商業乳品廠擔任乳品農場經理。隨後（自2022年1月至今），阿里加入穆罕默德·納瓦茲·謝里夫農業大學（Muhammad Nawaz Shareef University of Agriculture Multan, MNS-UAM）獸醫與動物科學系，擔任臨床醫學助理教授。他的研究興趣包括獸醫臨床醫學、無機半導體納米材料的綠色合成與表徵、聚合物納米結構、以及2D材料在對抗多重藥物抗性（MDR）病原體的催化、抗寄生蟲和抗菌評估方面的應用。

伊拉姆·沙赫扎迪博士於2019年在巴基斯坦拉合爾的旁遮普大學藥學學院（Punjab University College of Pharmacy, PUCP）獲得藥物化學碩士學位（M.Phil.），並獲得大學金獎。她於2024年在PUCP完成博士學位。2023年11月，伊拉姆加入拉合爾的管理與技術大學（University of Management and Technology, UMT）藥學院，擔任藥物化學助理教授。伊拉姆在2024年被史丹佛大學和Elsevier認定為全球前2%的科學家。她的研究興趣包括綠色合成、聚合物納米複合材料的合成與表徵，用於水處理、抗氧化和抗炎活性。她還專注於抗癌藥物的藥物負載和釋放機制，探索其對各種細胞系的細胞毒性潛力，以及計算研究，如計算模擬和密度泛函理論（DFT）研究。

塞赫里什·基蘭於2020年在巴基斯坦旁遮普省拉合爾的拉合爾女子大學（Lahore College for Women University, LCWU）獲得化學學士學位（B.S.）。塞赫里什於2022年在LCWU完成碩士學位（化學碩士，M.S.），其研究工作集中於利用農業廢料去除廢水中的重金屬。她的研究興趣包括聚合物和綠色納米材料的合成與表徵，針對藥物傳遞和治療、催化降解及殺菌評估。

卡沙夫·沙庫爾於2023年在巴基斯坦旁遮普省的費薩拉巴德政府大學（Government College University, Faisalabad, GCUF）獲得動物學學士學位（B.S.）。她目前在穆罕默德·納瓦茲·謝里夫農業大學（MNS-UAM）攻讀動物學碩士學位（M.S.）。她的研究興趣集中於聚合物納米結構的合成與表徵，並進行催化和殺菌評估，以克服畜牧業和水產業中的抗菌素抗性問題。

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