Carnitine Deficiency and Insufficiency in Medicine
暫譯: 醫學中的肉鹼缺乏與不足
Nakayama, Natsuki
- 出版商: Springer
- 出版日期: 2026-05-19
- 售價: $8,480
- 貴賓價: 9.5 折 $8,056
- 語言: 英文
- 頁數: 595
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 9819577969
- ISBN-13: 9789819577965
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相關主題
商品描述
This book provides an in-depth examination of carnitine, a crucial nutrient for mitochondrial function and energy metabolism. It explores the discovery, biochemical properties, and physiological roles of carnitine, offering a comprehensive understanding of its significance in human health.
The chapters cover a wide range of topics, including the carnitine cycle, its transport mechanisms, and the biochemical pathways it influences. Readers will gain insights into the nutrient's newly discovered roles, such as its anti-inflammatory, antioxidant, and anti-apoptotic effects. The book also addresses the clinical implications of carnitine deficiency, exploring its impact on inherited metabolic diseases, kidney and liver disorders, and cardiovascular health. With detailed discussions on the safety and pharmacokinetics of carnitine, this volume provides a balanced perspective on its therapeutic potential.
This book is an invaluable resource for medical professionals, researchers, and students in the fields of biochemistry, pharmacology, and clinical medicine. It offers a thorough exploration of carnitine's roles and applications, making it a must-read for those seeking to understand its impact on health and disease. By bridging the gap between basic science and clinical practice, this book equips readers with the knowledge needed to address the challenges of carnitine deficiency and harness its therapeutic benefits.
商品描述(中文翻譯)
本書深入探討了肉鹼（carnitine），這是一種對線粒體功能和能量代謝至關重要的營養素。書中探討了肉鹼的發現、生化特性及生理角色，提供了對其在人類健康中重要性的全面理解。
各章節涵蓋了廣泛的主題，包括肉鹼循環、其運輸機制以及其影響的生化途徑。讀者將深入了解這種營養素新發現的角色，例如其抗炎、抗氧化和抗凋亡的效果。本書還探討了肉鹼缺乏的臨床意義，分析其對遺傳性代謝疾病、腎臟和肝臟疾病以及心血管健康的影響。通過對肉鹼的安全性和藥物動力學的詳細討論，本書提供了對其治療潛力的平衡觀點。
本書是醫療專業人員、研究人員以及生物化學、藥理學和臨床醫學領域學生的寶貴資源。它對肉鹼的角色和應用進行了徹底的探討，對於那些希望了解其對健康和疾病影響的人來說，這是一本必讀的書籍。通過彌合基礎科學與臨床實踐之間的鴻溝，本書使讀者具備應對肉鹼缺乏挑戰和利用其治療益處所需的知識。
作者簡介
Dr. Natsuki Nakayama earned his Ph.D. in 1980 for his research on the biogenesis of plant mitochondria. He subsequently joined Otsuka Pharmaceutical, where he conducted research in cardiovascular and diabetes pharmacology before moving into clinical drug development for cardiovascular therapeutics.
In 2007, Dr. Nakayama began work on a specialized carnitine project. At that time, pharmaceutical-grade carnitine in Japan was approved solely for carnitine deficiency associated with methylmalonic acidemia and propionic acidemia. In 2011, he successfully broadened its indication to general "carnitine deficiency" without the need for clinical trials. He was further involved in the development of intravenous and oral liquid formulations, as well as in vitro diagnostic tools for identifying carnitine deficiency.
Because the term "carnitine deficiency" entered the Japanese medical community rather abruptly, many physicians and medical staff were initially unfamiliar with the condition. To address this gap, Dr. Nakayama delivered hundreds of lectures across Japan, explaining the physiological role of carnitine and the clinical significance of carnitine supplementation in deficiency states. Through these extensive educational and outreach efforts, he has come to be recognized as a rare and distinctive expert in the science and clinical application of carnitine.
作者簡介(中文翻譯)
中山夏樹博士於1980年獲得博士學位，研究主題為植物線粒體的生物生成。隨後，他加入大塚製藥，從事心血管和糖尿病藥理學的研究，之後轉向心血管治療藥物的臨床開發。
在2007年，中山博士開始專注於一個特殊的肉鹼項目。當時，在日本，藥品級肉鹼僅被批准用於與甲基丙二酸血症和丙酸血症相關的肉鹼缺乏症。2011年，他成功地將其適應症擴展至一般的「肉鹼缺乏症」，而無需進行臨床試驗。他還參與了靜脈注射和口服液劑型的開發，以及用於識別肉鹼缺乏症的體外診斷工具。
由於「肉鹼缺乏症」這一術語在日本醫學界的出現相當突然，許多醫生和醫療人員最初對這一病症並不熟悉。為了填補這一空白，中山博士在日本各地進行了數百場講座，解釋肉鹼的生理作用以及在缺乏狀態下肉鹼補充的臨床意義。通過這些廣泛的教育和宣傳努力，他被認可為肉鹼科學及其臨床應用方面的稀有且獨特的專家。
