Targeted Protein Degradation: Methods and Protocols

Cacace, Angela M., Hickey, Christopher M., Békés, Miklós

Targeted Protein Degradation: Methods and Protocols
  • 出版商: Humana Press
  • 出版日期: 2021-08-26
  • 售價: $8,500
  • 貴賓價: 9.5 折 $8,075
  • 語言: 英文
  • 頁數: 351
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 1071616641
  • ISBN-13: 9781071616642
  • 相關分類: 生物資訊 Bioinformatics

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This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.

Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.

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