An Introduction to Systems Biology: Design Principles of Biological Circuits, Second Edition

Praise for the first edition:

..".superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks." - Nature

" This text deserves] serious attention from any quantitative scientist who hopes to learn about modern biology... It assumes no prior knowledge of or even interest in biology... One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. ... Alon's book should become a standard part of the training of graduate students." - Physics Today

Written for students and researchers, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological systems. It highlights simple, recurring circuit elements that make up the regulation of cells and tissues. Rigorously classroom-tested, this edition includes new chapters on exciting advances made in the last decade.

Features:

• Includes seven new chapters
• The new edition has 189 exercises, the previous edition had 66
• Offers new examples relevant to human physiology and disease

第一版的好評如潮：

「這是一本出色、寫作精美且組織良好的工程方法論系統生物學著作。Alon 提供了精心撰寫的附錄，以清晰簡潔的方式解釋基本的數學和生物概念，而不會干擾主要內容。他從數學描述轉錄活化開始，然後描述了一些基本的轉錄網絡模式（模式），這些模式可以組合成更大的網絡。」- 《自然》雜誌

「這本書值得任何希望了解現代生物學的量化科學家的認真關注...它不需要任何對生物學的先備知識甚至興趣...最後必須提到的一個方面是每章附帶的精彩練習題...Alon 的書應該成為研究生培訓的標準一部分。」- 《物理學今日》雜誌

第二版針對學生和研究人員撰寫，這本暢銷教科書的第二版繼續清晰地介紹了控制生物系統結構和行為的設計原則。它強調了組成細胞和組織調節的簡單且重複出現的電路元件。經過嚴格的課堂測試，這版新增了關於過去十年取得的令人興奮的進展的新章節。

特點：

- 包含七個新章節
- 新版有189個練習題，之前的版本只有66個
- 提供與人體生理和疾病相關的新例子

Uri Alon is the Abisch-Frenkel professor of systems biology at the Weizmann Institute of Science

Uri Alon是以色列魏茨曼科學研究所的Abisch-Frenkel系統生物學教授。