The Mystery in the Rye: Ergot and LSD - A Cultural-Historical Quest
暫譯: 黑麥中的謎團：麥角酸鹽與LSD的文化歷史探索
Petersen, Frank
- 出版商: Springer
- 出版日期: 2025-04-05
- 售價: $2,570
- 貴賓價: 9.5 折 $2,441
- 語言: 英文
- 頁數: 229
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3662698145
- ISBN-13: 9783662698143
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相關分類:
化學 Chemistry
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商品描述
There are countless reports on microorganisms and their special abilities. The saga of the ergot fungus is perhaps the most unusual of them all. The unique history of this plant pathogenic microbe, which began with its infection of grasses, is told through a broad storyline that stretches from the early medical writings of Mesopotamia, Greece, and China, to the industrial and academic laboratories of pharmaceutical research in the 21st century....
Among cultivated grasses, the ergot fungus mainly infests rye. Its overwintering structure, the black-purple ergot kernel, grows out of the ears of the grain. The highly active substances it contains caused mass poisonings in Europe over a period of 1,000 years, in the course of which the victims suffered from terrible symptoms of illness. Only in the 17th century, doctors recognized ergot as the corpus delicti for the regularly recurring waves of mass poisoning. The development of drugs from pure ergot compounds is one of the fascinating contributions of pharmaceutical natural product and medicinal chemistry and was of great importance for the modernization of medicine. A straight line can be drawn from this research to the synthesis of LSD, whose accidentally observed psychotropic effect revealed the chemical basis of the psyche. In combination with other centrally active substances, the LSD studies opened the therapeutic research field of psychopharmacology.
The ergot fungus stands for legendary advances in pharmaceutical science and human therapy. At the same time, the people who investigated this unique microorganism scientifically, for a wide variety of reasons, became part of its cultural history. Throughout the centuries, they have kept the wheels turning - an innovative power which is still effective today.
商品描述(中文翻譯)
有關微生物及其特殊能力的報告不計其數。其中，麥角菌的故事或許是最不尋常的。這種植物病原微生物的獨特歷史，始於其對禾本科植物的感染，透過一個廣泛的故事情節講述，這個故事從美索不達米亞、希臘和中國的早期醫學著作，一直延伸到21世紀製藥研究的工業和學術實驗室。
在栽培的禾本科植物中，麥角菌主要侵擾黑麥。它的越冬結構，即黑紫色的麥角穀粒，從穀物的穗部長出。它所含的高度活性物質在歐洲造成了長達1,000年的大規模中毒事件，受害者遭受可怕的疾病症狀。直到17世紀，醫生才認識到麥角是定期發生的大規模中毒事件的犯罪證據。從純麥角化合物中開發藥物是藥物天然產物和藥物化學的一個迷人貢獻，對醫學的現代化具有重要意義。這項研究與LSD的合成之間可以劃出一條直線，LSD的意外觀察到的精神藥效揭示了心理的化學基礎。結合其他中樞活性物質，LSD的研究開啟了精神藥理學的治療研究領域。
麥角菌代表了藥物科學和人類治療的傳奇進步。與此同時，出於各種原因，科學研究這種獨特微生物的人們也成為其文化歷史的一部分。幾個世紀以來，他們不斷推動著進步的輪子，這種創新力量至今仍然有效。
作者簡介
Frank Petersen studied biology at the universities of Stuttgart-Hohenheim and Tübingen and has been the Head of the Natural Product department at the pharmaceutical company Novartis AG in Basel for many years. In his pharmaceutical research, the internationally renowned scientist focuses on the discovery, genetics, and production of novel active substances from fungi, bacteria, and plants as potential new therapeutics. In the context of implementing the "Convention on Biological Diversity", he has advised working groups at the European Union, the Swiss Federal Assembly, the German Federal Government, the World Trade Organization, and the United Nations. Invitations to guest professorships have taken him to Seoul, Korea, and Shanghai, China. For his contributions to microbial natural product research, he was awarded the "Senior Industrial Science Award 2020" by the Swiss Chemical Society. He is a member of the advisory board of "Swiss Youth in Science" and chairs the advisory committee of the Novartis Pavillon Basel.
作者簡介(中文翻譯)
Frank Petersen 在斯圖加特-霍亨海姆大學和圖賓根大學學習生物學，並在巴塞爾的製藥公司諾華（Novartis AG）擔任天然產品部門負責人多年。在他的製藥研究中，這位國際知名的科學家專注於從真菌、細菌和植物中發現、基因組學及生產新型活性物質，作為潛在的新療法。在實施《生物多樣性公約》的背景下，他曾為歐盟、瑞士聯邦議會、德國聯邦政府、世界貿易組織和聯合國的工作小組提供建議。他曾受邀擔任客座教授，前往韓國首爾和中國上海。因其對微生物天然產品研究的貢獻，他獲得了瑞士化學學會頒發的「2020年高級工業科學獎」。他是「瑞士青年科學」的顧問委員會成員，並擔任諾華巴塞爾展館的顧問委員會主席。
